Effects of Hyaluronic Acid on MDA-MB-231 Breast Cancer Cells

Abstract

Hyaluronic acid is a crucial part of the extracellular matrix and is involved in the development of cancer. Although HA is well known for its role in tissue hydration and cell proliferation, its effects on breast cancer cells are still being studied. With the focus of this study being on invasion, migration, apoptosis, and proliferation, this study examines how HA affects the behavior of breast cancer cells. Apoptotic marker expression, wound healing assays, and cell viability assays were used to examine the responses of breast cancer cells treated with different doses of HA using in vitro experiments. The study points to a dose dependent interaction, showing that HA inhibits cell growth at higher doses while promoting it at lower ones. Also, HA affected the pathways leading to cell migration and apoptosis, highlighting its dual function in tumor development. These results advance our knowledge of HA's potential as a therapeutic target or risk factor for the treatment of breast cancer. The molecular mechanisms behind these effects and their potential clinical outcome require more investigation.